Wednesday, October 1, 2014

Paul Ganjian's invitation is awaiting your response

 
 
Paul Ganjian would like to connect on LinkedIn. How would you like to respond?
Paul Ganjian
Paul Ganjian
Cosmetic Dentist Research Analyst
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Tuesday, September 23, 2014

I'd like to add you to my professional network on LinkedIn

 
Hi John,
I'd like to add you to my professional network on LinkedIn.
- Paul
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Paul Ganjian
Paul Ganjian
Cosmetic Dentist Research Analyst
Greater New York City Area
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Paul Ganjian
Paul Ganjian
Cosmetic Dentist Research Analyst
Sirin Samman
Sirin Samman
Photographer | Designer | Writer
Jay Levine
Jay Levine
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Friday, July 27, 2012

Vitamin K And Metabolism

Vitamin K is essential for the synthesis of proteins belonging to the Gla-protein family. To the members of this family belong four blood coagulation factors, which all are exclusively formed in the liver. The importance of vitamin K for hemostasis is demonstrated from the fact that vitamin K-deficiency is an acute, life-threatening condition due to excessive bleeding. Other members of the Gla-protein family are osteocalcin, matrix Gla-protein (MGP), and Gas6 that play key functions in maintaining bone strength, arterial calcification inhibition, and cell growth regulation, respectively. In total 17 Gla-proteins have been discovered at this time. Recently, it was observed that the dietary vitamin K requirement for the synthesis of the coagulation factors is much lower than for that of the extra-hepatic Gla-proteins. This forms the basis of the triage theory stating that during poor dietary supply, vitamins are preferentially utilized for functions that are important for immediate survival. This explains why in the healthy population all clotting factors are synthesized in their active form, whereas the synthesis of other Gla-proteins is sub-optimal in non-supplemented subjects. Prolonged sub-clinical vitamin K deficiency is a risk factor for osteoporosis, atherosclerosis, and cancer. Present recommendations for dietary intake are based on the daily dose required to prevent bleeding. Accumulating scientific data suggests that new, higher recommendations for vitamin K intake should be formulated.